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Contact Us Careers News Events About About Leadership News Events Careers Contact Us People People Faculty Core Faculty Junior Faculty Associate Faculty T32 Faculty Trainees Postdocs Students Others Staff New Members All People Directory Research Research Laboratories Aguirre Lab Bernstein Lab Castro Lab Higgins Lab Im Lab Lee Lab Lin Lab Miller Lab Naxerova Lab Nahrendorf Lab Pittet Lab Swirski Lab Weissleder Lab Programs Biomedical Engineering Clinical Trials Cancer Immunology Cardio-Immunology Membrane Biology Cores Mouse Imaging Research Infomatics Publications Publications Publications Papers Journal Covers Highlights Contact us Careers News Events Leadership News Events Careers Contact Us Faculty Core Faculty Junior Faculty Associate Faculty T32 Faculty Trainees Postdocs Students Others Staff New Members All People Directory Laboratories Aguirre Lab Bernstein Lab Castro Lab Higgins Lab Im Lab Lee Lab Lin Lab Miller Lab Naxerova Lab Nahrendorf Lab Pittet Lab Swirski Lab Weissleder Lab Programs Biomedical Engineering Clinical Trials Cancer Immunology Cardio-Immunology Membrane Biology Cores Mouse Imaging Research Infomatics Publications Papers Journal Covers Highlights For over 10 years we have played a central role in the growth of human life sciences and the revolution in analyzing complex systems. The Center has particular strength in complex human conditions such as cancer, cardiovascular disease, inflammation and degeneration. Read More Faculty Ralph Weissleder John Higgins Miles Miller Aaron Aguirre Hyungsoon Im Kamila Naxerova Bradley Bernstein Hakho Lee Matthias Nahrendorf Cesar Castro Charles Lin Mikael Pittet Fil Swirski Research Focus Imagine , if we understood what the 30 trillions of cells in our body do at any given moment... Now compare these 30 trillions of cells (not counting the microbiome!) to the earth population of 8B people (3,750 times more!). This creates a massive undertaking... At CSB we develop innovative technologies to enable the discovery of new biology, drug targets and diagnostics. Approach: we develop new integrated systems for subcellular analysis and use innovative imaging tools to decipher dynamic networks. This allows us to interrogate networks at multiple scales from populations to molecules. Research Highlights (read more...) CSB work discovers exercise benefits on bone marrow Modern life comes with many dangers. This includes sedentary behavior, as we all spend increasing time sitting: on the office chair, in the car, and on the sofa. This is risky and leads to obesity, myocardial infarction and stroke. A manuscript published in Nature Medicine describes a new pathway how sedentary behavior causes cardiovascular disease. Mice with access to treadmills had lower blood st Learn more... Discovering Myeloid Cells In Lung Tumors Myeloid cells can promote or limit tumor outgrowth but remain poorly understood. In a study published in Immunity, the Pittet lab at the MGH Center for Systems Biology and the Klein lab at Harvard Medical School teamed up to map myeloid cells at the single cell level in human and mouse lung cancer. They made the following findings: 1) Consistent complexity: the same tumor myeloid populations are re Learn more... Study helps solve mystery of how sleep protects against heart disease Researchers say they are closer to solving the mystery of how a good night’s sleep protects against heart disease. In studies using mice, they discovered a previously unknown mechanism between the brain, bone marrow, and blood vessels that appears to protect against the development of atherosclerosis, or hardening of the arteries—but only when sleep is healthy and sound. The discovery of this pathw Learn more... Recent Publications Hulsmans M, Nahrendorf M Proliferative, degradative smooth muscle cells promote aortic disease. J Clin Invest. 2020;:ePub - PMID: 32039919 - DOI: 10.1172/JCI134019 Malka R, Brugnara C, Cialic R, Higgins JM Non-Parametric Combined Reference Regions and Prediction of Clinical Risk. Clin Chem. 2020;66(2):363-372 - PMID: 32040586 - DOI: 10.1093/clinchem/hvz020 Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, Calogero RA, Schroeder T, Lin CP, Camargo FD Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020;:ePub - PMID: 32025033 - DOI: 10.1038/s41586-020-1971-z Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum. J Clin Endocrinol Metab. 2020;:ePub - PMID: 32010954 - DOI: 10.1210/clinem/dgaa053 More publications ... Upcoming Events 2020-02-19 Conquering the K: Applying for an NIH Career Development Award: Fundamental Research Track Various 2020-02-20 Harvard Program in Therapeutic Science (HitS) Miles Miller, PhD 2020-02-20 Conquering the K: Applying for an NIH Career Development Award: Clinical Investigator Track Various 2020-02-24 Multimodal Multitask Representation Learning for Pathology Biobank Metadata Prediction Wei-Hung Weng, MD, MMSc 2020-02-25 Blacks in Science, Engineering and Medicine: An Imperative to Accelerate Achievement and Optimize Opportunity Charles R. Bridges, MD, ScD, HMS Tweets by MGHCSB Donate Your donation supports cutting-edge research at the MGH Center for Systems Biology Center for Systems Biology © 2007 - 2020 Center for Systems Biology Privacy Policy...