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Contact Us Careers News Events About About About Leadership News Careers Contact Us People People Faculty Core Faculty Junior Faculty Associate Faculty T32 Faculty Alumni Faculty Trainees Postdocs Students Others Staff New Members Alumni All People Directory Research Research Laboratories Aguirre Lab Castro Lab Carlson Lab Garris Lab Higgins Lab Hulsmans Lab Hwang Lab Im Lab Lee Lab Lin Lab Miller Lab Nahrendorf Lab Weissleder Lab Programs Biomedical Engineering Clinical Trials Cancer Immunology Cardio-Immunology Cores Mouse Imaging Research Infomatics Publications Publications Publications Papers Journal Covers Software Highlights Contact us Careers News Events About Leadership News Careers Contact Us Faculty Core Faculty Junior Faculty Associate Faculty T32 Faculty Alumni Faculty Trainees Postdocs Students Others Staff New Members Alumni All People Directory Laboratories Aguirre Lab Castro Lab Carlson Lab Garris Lab Higgins Lab Hulsmans Lab Hwang Lab Im Lab Lee Lab Lin Lab Miller Lab Nahrendorf Lab Weissleder Lab Programs Biomedical Engineering Clinical Trials Cancer Immunology Cardio-Immunology Cores Mouse Imaging Research Infomatics Publications Papers Journal Covers Software Highlights Today at 1:00pm: Introduction to Image Analysis using ImageJ/Fiji For over 10 years we have played a central role in the growth of human life sciences and the revolution in analyzing complex systems. The Center has particular strength in complex human conditions such as cancer, cardiovascular disease, inflammation and degeneration. Read More Faculty Aaron Aguirre John Higgins Hakho Lee Jonathan Carlson Maarten Hulsmans Charles Lin Cesar Castro William Hwang Miles Miller Christopher Garris Hyungsoon Im Matthias Nahrendorf Ralph Weissleder Open Positions Recent Publications Halabi EA, Gessner I, Yang K,..., Weissleder R Magnetic Silica-Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor-Associated Proteins. Angew Chem Int Ed Engl. 2024;:e202318870 - PMID: 38578432 - DOI: 10.1002/anie.202318870 Guan D, Men Y, Bartlett A,..., Ozcan U Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss. Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007 Wu Q, Zhang J, Kumar S,..., Lucas D Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6 Rosenthal ZC, Fass DM, Payne NC,..., Haggarty SJ Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia. Sci Rep. 2024;14(1):9064 - PMID: 38643236 - PMCID: PMC11032351 - DOI: 10.1038/s41598-024-59110-7 Research Focus Imagine , if we understood what the 30 trillions of cells in our body do at any given moment... Now compare these 30 trillions of cells (not counting the microbiome!) to the earth population of 8B people (3,750 times more!). This creates a massive undertaking... At CSB we develop innovative technologies to enable the discovery of new biology, drug targets and diagnostics. Approach: we develop new integrated systems for subcellular analysis and use innovative imaging tools to decipher dynamic networks. This allows us to interrogate networks at multiple scales from populations to molecules. Research Highlights (read more...) Coaxing macrophages to fight cancer Our previous work found that high levels of tumor macrophages expressing the chemokine CXCL9 are associated with good clinical outcomes in cancer patients. Unfortunately, most tumor-associated macrophages do not express CXCL9. In this study, we develop a macrophage image screening approach to identify drugs that potentiate CXCL9 production. Here, we show a triplet drug combination incorporated into a macrophage-avid nanoparticle that strongly enhances macrophage CXCL9 production and triggers remarkable anti-tumor efficacy in mouse cancer models. We envision leveraging deep molecular analysis of anti-tumor macrophages with novel drug screening methods to develop new cancer treatment methods. Learn more... Probing extracellular vesicles promises early detection of ovarian cancer Ovarian cancer poses challenges for early detection due to its nonspecific symptoms, often resulting in late-stage diagnosis. This study aimed to address this issue by investigating extracellular vesicles (EVs) as an early biomarker for ovarian cancer, specifically focusing on high-grade serous ovarian carcinoma (HGSOC). Leveraging the growing understanding that HGSOC originates from precursor lesions in the fallopian tube, the researchers examined EVs derived from murine fallopian tube (mFT) cells with oncogenic mutations and identified candidate markers specific to fallopian tube origins. In a pilot study involving human patients, these EV markers were validated for their high accuracy in distinguishing HGSOC from non-cancer cases. This innovative approach would offer a minimally invasive method to monitor women at high risk of ovarian cancer, facilitating timely intervention strategies. Learn more... Electrical engineering to boost electrochemiluminescence Electrochemiluminescence (ECL) is a powerful biosensing method with inherently low background and precise chemical reactions through electrical control. In recent work published in Science Advances , CSB investigators extended ECL’s advantages by devising a new system termed ECLipse (ECL in paired signal electrode). The key innovation was to separate ECL generation from target detection: these two processes were carried out in isolated chambers and coupled through an electrode. With this strategy, the investigators could maximize the analytical signal without crosstalk and integrate multiple sensors in a compact chip. In a pilot clinical study, the ECLipse system accurately detected septic conditions by measuring host factors (IL-3, IL-6, PCT) and revealed distinct IL-3 and IL-6 patterns in patients with SARS-CoV-2 infection. Learn more... Follow @MGHCSB Upcoming Events 2024-05-14 Introduction to Image Analysis using ImageJ/Fiji 2024-05-15 Introduction to Image Analysis using ImageJ/Fiji 2024-05-16 Cancer Center Grand Rounds TBD 2024-05-16 Reprogramming the immune response through biomolecular engineering Jamie Spangler, Ph.D. 2024-05-20 Introduction to Bioimage Analysis using QuPath Donate Your donation supports cutting-edge research at the MGH Center for Systems Biology Center for Systems Biology © 2007 - 2024 Center for Systems Biology Privacy...